Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide
نویسندگان
چکیده
منابع مشابه
The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.
Pyrazinamide (PZA) is an important front line anti-tuberculosis drug because of its sterilizing activity against semi-dormant tubercle bacilli. In spite of its remarkable role in shortening the treatment duration from 9 months to 6 months when used in combination with Rifampicin and Isoniazid, PZA remains a difficult paradox because of its incompletely understood mode of action and mechanism of...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2019
ISSN: 0165-6147
DOI: 10.1016/j.tips.2019.10.005